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KMID : 0032220120240020181
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Annals of Dermatology
2012 Volume.24 No. 2 p.181 ~ p.188
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The Effect of Adipose-Derived Stem Cell-Cultured Media on Oxazolone Treated Atopic Dermatitis-Like Murine Model
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Lee Hae-Jin
Jung Min-Young
Kim Jae-Hong
Yoon Na-Young
Choi Eung-Ho
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Abstract
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Background: A stem cell is an undifferentiated cell that has the potential for self-renewal and differentiation. Adipose- derived stem cells (ADSCs) have advantages in accessibility and abundance compared to other kinds of stem cells and produce many growth factors and hormones.
Objective: We investigated whether ADSC cultured media could be used as a therapy for atopic dermatitis.
Methods: ADSC cultured media was topically applied twice daily for 5 days to oxazolone-treated atopic dermatitis-like hairless mice.
Results: Topical application of ADSC cultured media improved the epidermal permeability barrier and keratinocyte differentiation, and restored the predominant Th2 phenotype when compared to vehicle. ADSC cultured media- treated epidermis also showed an increase in the expression of antimicrobial peptides cathelin-related antimicrobial peptide, mouse beta-defensein 3.
Conclusion: Topical ADSC cultured media could be useful in the treatment of atopic dermatitis. (Ann Dermatol 24(2) 181∼188, 2012)
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KEYWORD
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Adipose-derived stem cell, Atopic dermatitis, Oxazolone
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